Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association

The abstract describes STRIDE (Stanford Translational Research Integrated Database Environment), a research and development project at Stanford University to create a standards-based informatics platform supporting clinical and translational research. STRIDE consists of three integrated components: a clinical data warehouse based on the HL7 Reference Information Model (RIM) containing clinical information on over 1.3 million pediatric and adult patients cared for at Stanford University Medical Center since 1995; an application development framework for building research data management applications on the STRIDE platform; and a biospecimen data management system.

STRIDE's semantic model uses standardized terminologies such as SNOMED, RxNorm, ICD, and CPT to represent important biomedical concepts and their relationships. The system is in daily use at Stanford and is described as an important component of Stanford University's Clinical and Translational Science Award (CTSA) Informatics Program, illustrating how standardized data models and vocabularies can underpin institution-wide clinical research infrastructure.