ColabFold: making protein folding accessible to all

ColabFold is an open-source platform that speeds up protein structure and complex prediction by combining the fast homology search of MMseqs2 with the AlphaFold2 or RoseTTAFold folding models. This pairing replaces slower search steps and optimizes how the models are used, making high-quality structure prediction available to a broad audience.

The system runs a 40-60-fold faster search and, through optimized model utilization, can predict close to 1,000 structures per day on a server with a single graphics processing unit. Delivered through Google Colaboratory as free, open-source software with novel environmental databases, ColabFold made advanced protein folding widely accessible to researchers.