BioGRID: a general repository for interaction datasets

BioGRID is a freely accessible general repository for interaction datasets, created because unified access to protein and genetic interaction data is critical for interrogating gene and protein function and analyzing global network properties. Release version 2.0 includes more than 116,000 physical and genetic interactions drawn from four organisms: Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens. Over 30,000 of these interactions were recently added through exhaustive curation of the S. cerevisiae primary literature, spanning 5,778 sources.

The database provides an internally hyper-linked web interface for rapid search and retrieval, and lets users freely download full or custom datasets as tab-delimited text files and PSI-MI XML. Pre-computed graphical layouts of interactions are offered in several file formats, and users can build customized graphs with embedded protein, gene, and interaction attributes through the Osprey visualization system, which is dynamically linked to BioGRID. By consolidating curated interactions with accessible tools, BioGRID became a widely used resource for interaction and network biology.